Platelet-Rich Fibrin (PRF)
Platelets from the blood plasma contain a high concentration of essential growth factors that stimulate cell migration and proliferation, thus supporting wound healing. This property of platelets was used in the first generation of plasma concentrate from autologous (or one’s own) blood, where platelet-rich plasma or PRP was introduced to expedite healing. The second generation of plasma concentrate uses platelet-rich fibrin or PRF that is less cumbersome to extract and has a very low risk of contamination.
Fibrin is a fibrous mesh formed during the process of blood clotting to impede the flow of blood. It contains high concentrations of essential growth factors, platelets, lymphocytes, monocytes, stem cells, and granulocytes that connect with the tissue and help with faster bone and soft tissue regeneration.
To get PRF for your treatment, about 10 ml of venous blood is taken, added to sterile glass tubes, and centrifuged for a few minutes. The fibrin clot is formed in the middle layer and placed on the surgical site as a clot.
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